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Disclaimer: This table primarily focuses on reconstructed human tissues. The information provided in this table is sourced from various suppliers and may not be complete or fully accurate. Inclusion of any supplier or product does not imply endorsement or recommendation. Chemically defined medium definition is based on Chary et al. 2022.
| Tissue model name | Supplier | Organ/system | Tissue detail | Cell types | Chemically defined media | Facilities | Included in OECD Test Guideline? |
|---|---|---|---|---|---|---|---|
| SkinEthic HBE | EpiSkin, L’oreal | Bladder | Bladder epithelium | Immortalized human bladder epithelial cells (RT-112) | Yes | ||
| 3D Osteochondral Model | Alcyomics® | Cartilage | Cartilage | Mesenchymal stem cell-derived chondrocytes and osteoblasts | |||
| Cartilage model | BioSolution | Cartilage | Cartilage | Primary human chondrocytes | |||
| LabCyte CORNEA-MODEL | Japan Tissue Engineering | Eye | Corneal epithelium | Primary human corneal epithelial cells | No | Japan | TG 492 |
| EpiCorneal™ | MatTek Life Sciences | Eye | Corneal epithelium | Primary human corneal epithelial cells | No | ||
| EpiOcular™ | MatTek Life Sciences | Eye | Corneal epithelium | Primary human epidermal keratinocytes | No | USA/Slovakia | TG 492 |
| Retinal Pigment Epithelium | Newcells Biotech | Eye | Retinal Pigment Epithelium | iPSC-derived retinal pigment cells | |||
| MCTT HCE™ | BioSolution | Eye | Corneal epithelium | Primary human corneal epithelial cells | South Korea | TG 492 | |
| SkinEthic™ HCE | EpiSkin, L’oreal | Eye | Corneal epithelium | Transformed human corneal keratinocytes | Yes | France | TG 492, TG 492B |
| EpiIntestinal™ | MatTek Life Sciences | Gut | Small intestine epithelium | Primary human small intestinal epithelial cells | No | ||
| EpiIntestinal™ FT | MatTek Life Sciences | Gut | Small intestine epithelium and interstitium | Primary human small intestinal epithelial cells and fibroblasts | No | ||
| RepliGut® Planar | Altis Biosystems | Gut | Small Intestine (duodenum, jejunum, iIleum) or Colon (ascending, transverse or descending) | Primary human intestinal epithelial cells | |||
| NuHeart™ | InvivoSciences | Heart | Heart microtissues | iPSC-derived cardiomiocytes | |||
| hvCTS | Novoheart™ | Heart | Heart microtissues | iPSC-derived cardiomiocytes | |||
| hvCOC, Human Heart-in-a-Jar | Novoheart™ | Heart | Heart microtissues | iPSC-derived cardiomiocytes | |||
| EpiKidney™(beta) | MatTek Life Sciences | Kidney | Nephron (kidney proximal tubule epithelium) | Primary human proximal tubule epithelial cells | No | ||
| aProximate™ | Newcells Biotech | Kidney | Nephron (kidney proximal tubule epithelium) | Primary human proximal tubule epithelial cells | Yes | ||
| 3D InSight™ Human Liver Microtissues | InSphero | Liver | Hepatocytes & Kupfer cells | Primary human hepatocytes, stromal cells (hepatic endothelial cells) and Kupffer cells | |||
| TruVivo® | LifeNet Health | Liver | Hepatocytes | Primary human hepatocytes, stromal cells (inc. endothelial cells) | |||
| EpiLiver™(beta) | MatTek Life Sciences | Liver | Hepatocytes | Primary human hepatocytes | No | ||
| Hepatopac® | BioIVT | Liver | Hepatocytes | Primary human hepatocytes or immortalized hepatocytes (upcyte®), and stromal cells | No | ||
| Hepatomune® | BioIVT | Liver | Hepatocytes & Kupfer cells | Primary human hepatocytes or immortalized hepatocytes (upcyte®), stromal cells and Kupffer cells | |||
| Liver model | BioSolution | Liver | Hepatocytes | Stem cell-derived liver cells | |||
| BrainSim® | AxoSim | Nervous system | Central nervous system (brain) | iPSC-derived neurons and glial cells (astrocytes and oligodendrocytes) | |||
| microBrain™ | AxoSim | Nervous system | Central nervous system (brain) | iPSC-derived cortical neurons and glial cells (astrocytes) | |||
| NerveSim® | AxoSim | Nervous system | Peripheral nervous system (nerves) | iPSC derived neurons and glial cells (Schwann cells) | |||
| Dopaminergic neuron model | BioSolution | Nervous system | Central nervous system (brain) | Stem cell-derived dopaminergic neurons | |||
| EpiGingival™ | MatTek Life Sciences | Oral | Gingival epithelium | Primary human gingival keratinocytes | No | ||
| EpiGingival™ FT | MatTek Life Sciences | Oral | Gingival epithelium | Primary human gingival keratinocytes and fibroblasts | No | ||
| EpiOral™ FT LC | MatTek Life Sciences | Oral | Oral epithelium | Primary human oral keratinocytes and Langerhans cells | No | ||
| EpiOral™ | MatTek Life Sciences | Oral | Oral epithelium | Primary human oral keratinocytes | No | ||
| EpiOral™ FT | MatTek Life Sciences | Oral | Oral epithelium | Primary human oral keratinocytes and fibroblasts | No | ||
| SoluOral™ | BioSolution | Oral | Oral epithelium | Oral mucosal epithelial cells | |||
| SkinEthic™ HGE | EpiSkin, L’oreal | Oral | Gingival epithelium | Primary human gingival keratinocytes | Yes | ||
| SkinEthic™ HO2E | EpiSkin, L’oreal | Oral | Oesophageal epithelium | Immortalized oesophageal epithelial cells (Kyse 510) | Yes | ||
| SkinEthic™ HOE | EpiSkin, L’oreal | Oral | Oral epithelium | Immortalized oral epithelial cells (TR146) | Yes | ||
| 3D InSight™ Human Islet Microtissues | InSphero | Panchreas | Reaggreated human islet cells | Primary human islet cells | |||
| Islet model | BioSolution | Panchreas | Stem cells-derived islets | Stem cell-derived human islet cells | |||
| ALIsens | Invitrolize | Respiratory | Alveolar epithelium | Immortalized alveolar epithelial cells (A549), immortalized endothelial cells (EA.hy926), immortalized macrophage-like cells (dTHP-1) and immortalized dendritic-like cells (THP-1) | No | ||
| EpiNasal™(beta) | MatTek Life Sciences | Respiratory | Nasal epithelium | Primary human nasal epithelial cells | No | ||
| EpiAirway™ | MatTek Life Sciences | Respiratory | Tracheobronchial epithelium | Primary human tracheal/bronchial epithelial cells | No | ||
| EpiAirway™ FT | MatTek Life Sciences | Respiratory | Tracheobronchial epithelium | Primary human tracheal/bronchial epithelial cells and stromal fibroblasts | No | ||
| EpiAlveolar™ | MatTek Life Sciences | Respiratory | Alveolar epithelium | Primary alveolar epithelial cells (type I and II), pulmonary fibroblasts and pulmonary endothelial cells (possible with immortalized macrophage-like cells, THP-1) | No | ||
| Small Airway Epithelial Cell Model | Newcells Biotech | Respiratory | Small airway (bronchiolar) epithelium | Small airway epithelial cells | |||
| SoluAirway™ | BioSolution | Respiratory | Tracheobronchial epithelium | Primary human tracheal/bronchial epithelial cells | |||
| MucilAir™ | Epithelix | Respiratory | Nasal, tracheal or bronchial epithelium | Primary human nasal, tracheal or bronchial epithelial cells | Yes | ||
| MucilAir™ HF | Epithelix | Respiratory | Nasal, tracheal or bronchial epithelium incl. fibroblasts | Primary human nasal, tracheal or bronchial epithelial cells and fibroblasts | Yes | ||
| SmallAir™ | Epithelix | Respiratory | Small airway (bronchiolar) epithelium | Small airway epithelial cells | Yes | ||
| SmallAir™ HF | Epithelix | Respiratory | Small airway (bronchiolar) epithelium | Small airway epithelial cells and fibroblasts | Yes | ||
| AlveolAir™ | Epithelix | Respiratory | Alveolar epithelium | Alveolar epithelial cells (type I and II) and endothelial cells | Yes | ||
| HiTrach | HiLung | Respiratory | Tracheobronchial epithelium | iPSC-derived tracheal epithelial cells | |||
| HiAlv | HiLung | Respiratory | Alveolar epithelium | iPSC-derived alveolar epithelial cells | |||
| ImmuLUNG™ | ImmuONE™ | Respiratory | Alveolar epithelium | Immortalized human alveolar epithelial cells and alveolar macrophage-like | |||
| EpiSkin™ Human Epidermis | EpiSkin, L’oreal | Skin | Reconstructed epidermis | Primary human keratinocytes | France | TG 431 | |
| LabCyte EPI-MODEL | Japan Tissue Engineering | Skin | Reconstructed epidermis | Primary human keratinocytes | No | Japan | TG 431, TG 439 |
| LabCyte EPI-MODEL 6D | Japan Tissue Engineering | Skin | Reconstructed epidermis | Primary human keratinocytes | No | ||
| EpiDerm™ | MatTek Life Sciences | Skin | Reconstructed epidermis | Primary human keratinocytes | No | USA/Slovakia | TG 431, TG 439, TG 498 |
| EpiDerm™ FT | MatTek Life Sciences | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) | Primary human keratinocytes & fibroblasts | No | ||
| MelanoDerm™ | MatTek Life Sciences | Skin | Reconstructed epidermis (pigmented) – Caucasian, African or Asian | Primary human keratinocytes & melanocytes | No | ||
| Phenion® FT Skin Model | Phenion | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) | Primary human keratinocytes & fibroblasts | Germany | Alternative for TG439 | |
| Phenion® FT LONG-LIFE | Phenion | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) – aged | Primary human keratinocytes & fibroblasts | |||
| Phenion® FT AGED | Phenion | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) – senescent | Primary human keratinocytes & fibroblasts | |||
| Skimune® | Alcyomics® | Skin | Full thickness reconstructed skin tissue (explant) – dermis, epidermis; incl. Blood samples | Full thickness skin tissue (explant) incl. Peripheral Blood Mononuclear Cells | |||
| Skimune® Epi | Alcyomics® | Skin | Reconstructed epidermis | Primary human keratinocytes | UK | Alternative for TG 431 & TG 439 | |
| Skimune 3D® | Alcyomics® | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) | Primary human keratinocytes & fibroblasts | |||
| 3D Innervated Skin Model | Alcyomics® | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) incl. neurons | Primary human keratinocytes & fibroblasts, incl. iPSC-derived Schwann cells & neurons | |||
| 3D bioprinted | Atlantis Bioscience | Skin | Reconstructed epidermis (pigmented) | Primary human keratinocytes, melanocytes, immune cells (macrophages), sebocytes & endothelial cells | |||
| Adult human skin, full thickness | Atlantis Bioscience | Skin | Full thickness skin tissue (explant) – dermis, epidermis | Full thickness skin tissue (explant) | |||
| KeraSkin™ | BioSolution | Skin | Reconstructed epidermis (Korean) | Primary human keratinocytes | South Korea | TG 439 | |
| KeraSkin-M™ | BioSolution | Skin | Reconstructed epidermis (pigmented) – Korean | Primary human keratinocytes & melanocytes | |||
| KeraSkin-FT™ | BioSolution | Skin | Full thickness thickness skin (epidermis & dermis) – Korean | Primary human keratinocytes & fibroblasts | |||
| CTISkin® | CTIBiotech | Skin | Full thickness skin tissue (explant) – dermis, epidermis | Full thickness skin tissue (explant) | |||
| Sebocyte 3D model | CTIBiotech | Skin | Hypodermis – Sebaceous gland | Sebocytes | |||
| DNSkin™ | DeNova Sciences | Skin | Reconstructed epidermis (Asian) | Primary human keratinocytes | Yes | ||
| DNSKinFT™ | DeNova Sciences | Skin | Full thickness thickness skin (Asian) | Primary human keratinocytes & fibroblasts | Yes | ||
| SkinEthic™ RHE-LC | EpiSkin, L’oreal | Skin | Reconstructed epidermis & Langerhans | Primary human keratinocytes & Langerhans cells | |||
| SkinEthic™ RHE | EpiSkin, L’oreal | Skin | Reconstructed epidermis | Primary human keratinocytes | Yes | France | TG 431, TG 439 |
| SkinEthic™ RHPE | EpiSkin, L’oreal | Skin | Reconstructed epidermis (pigmented) | Primary human keratinocytes & melanocytes | |||
| T-Skin™ | EpiSkin, L’oreal | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) | Primary human keratinocytes & fibroblasts | |||
| NativeSkin® | Genoskin | Skin | Full thickness skin tissue (explant) – dermis, epidermis | Full thickness skin tissue (explant) | Yes | ||
| HypoSkin® | Genoskin | Skin | Full thickness skin tissue (explant) – dermis, epidermis & hypodermis (adipose) | Full thickness skin tissue (explant) | Yes | ||
| Silabskin® RE | Silab | Skin | Reconstructed epidermis | Primary human keratinocytes | |||
| Silabskin® FT | Silab | Skin | Full thickness thickness skin (epidermis & dermis) | Primary human keratinocytes & fibroblasts | |||
| Straticell RHE | StratiCELL | Skin | Reconstructed epidermis | Primary human keratinocytes | |||
| Straticell RHE-huSN | StratiCELL | Skin | Reconstructed epidermis & sensory neurons | Primary human keratinocytes & iPSC-derived sensory neurons | |||
| Straticell RHE-MEL | StratiCELL | Skin | Reconstructed epidermis (pigmented) | Primary human keratinocytes & melanocytes | |||
| Straticell adipose model | StratiCELL | Skin | Hypodermis tissue (adipose) | Human white pre-adipocytes, human differentiated white adipocytes, or immortalized mouse preadipocyte cells (3T3L1) | |||
| LabSkin Reconstructed Human Epidermis | Labskin Creations | Skin | Reconstructed epidermis | Primary human keratinocytes | |||
| Bioprinted Human Pigmented Epidermis | Labskin Creations | Skin | Reconstructed epidermis (pigmented) | Primary human keratinocytes & melanocytes | |||
| 3D ADIPOPrint | Labskin Creations | Skin | Hypodermis tissue (adipose) | Adipose stem cell-derived adipocytes | |||
| 3D PIGMENTSkin | Labskin Creations | Skin | Full thickness reconstructed skin tissue (epidermis & dermis, pigmented) | Primary human keratinocytes, fibroblasts & melanocytes | |||
| 3D SEBOSkin | Labskin Creations | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) incl. sebaceous glands | Primary human keratinocytes, fibroblasts & iPSC-derived sebocytes | |||
| 3D VASCULOSkin | Labskin Creations | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) incl. endothelial cells | Primary human keratinocytes, fibroblasts & endothelial cells | |||
| Full Thickness Skin Model | Creative Bioarray | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) | Primary human keratinocytes & fibroblasts | |||
| Neurodermatology Cell Model | Creative Bioarray | Skin | Full thickness reconstructed skin tissue (epidermis & dermis) incl. sensory neurons | Primary human keratinocytes, sensory neurons | |||
| Pigmented Skin Model | Creative Bioarray | Skin | Full thickness reconstructed skin tissue (epidermis & dermis, pigmented) | Primary human keratinocytes, fibroblasts & melanocytes | |||
| Reconstructed Human Epidermis | Creative Bioarray | Skin | Reconstructed epidermis | Primary human keratinocytes | |||
| Ex vivo explants | Creative Bioarray | Skin | Full thickness skin tissue (explant) – dermis, epidermis | Full thickness skin tissue (explant) | |||
| EpiVaginal™ | MatTek Life Sciences | Vagina | Vaginal epithelium | Primary human ectocervical cells (custom: + dendritic cells) | No | ||
| EpiVaginal™ FT | MatTek Life Sciences | Vagina | Vaginal epithelium | Primary human ectocervical cells and fibroblasts (custom: + dendritic cells) | No | ||
| SkinEthic™ HVE | EpiSkin, L’oreal | Vagina | Vaginal epithelium | Immortalized human vaginal epithelial cells (A431) | Yes |