In Vitro Methods for Skin Irritation and Corrosion Testing

Reference Documents

2018 PETA Science Consortium International and Chemical Watch webinar series featuring Dr. Gertrude-Emilia Costin (Institute for In Vitro Sciences) and Dr. Costanza Rovida (TEAM Mastery and CAAT-Europe) speaking on skin irritation and corrosion

OECD TG 439: In vitro skin irritation: Reconstructed human epidermis test method

OECD TG 431: In vitro skin corrosion: Reconstructed human epidermis test method

OECD TG 435: In vitro membrane barrier test method for skin corrosion

OECD TG 430: In vitro skin corrosion: Transcutaneous electrical resistance test method

OECD guidance on an integrated approach to testing and assessment (IATA) for skin corrosion and irritation (July 2014): Series on testing and assessment, No. 203

OECD guidance on considerations for waiving or bridging of mammalian acute toxicity tests (August 2016): Series on testing and assessment, No. 237

OECD guidance on describing non-guideline in vitro test methods (December 2014): Series on testing and assessment, No. 211

ECHA guidance on skin irritation/corrosion

De Jong et al. Round robin study to evaluate the reconstructed human epidermis (RhE) model as an in vitro skin irritation test for detection of irritant activity in medical device extracts. Toxicol in Vitro. 2018;accepted manuscript.

Casas et al. In vitro human skin irritation test for evaluation of medical device extracts. Toxicol in Vitro. 2013;27(8): 2175–2183.