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ShareThe Organisation for Economic Co-operation and Development Test Guideline (OECD TG) 492: Reconstructed human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage, was updated. The TG now includes two commercially available RhCE models: MatTek’s EpiOcular™ model and the SkinEthic™ Human Corneal Epithelium (HCE) model.
Other recent updates to existing OECD TGs include the following:
- OECD TG 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage
- OECD TG 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants
- OECD TG 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage
- OECD TG 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage
- OECD TG 402: Acute Dermal Toxicity (which includes a reduction in animal use compared to the previous version)
Additionally, the OECD has released a new TG for the assessment of acute inhalation toxicity (OECD TG 433: Fixed Concentration Procedure) that uses evident toxicity to classify a test chemical instead of death or moribundity of animals and is a refinement and reduction compared to existing acute inhalation toxicity test guidelines (i.e. TGs 403 and 436).