Three years after the extended one-generation reproductive toxicity test (EORGTS) – which has the potential to halve the number of animals used in reproductive tests – was accepted by the OECD, the EORGTS has been incorporated into the REACH Annexes. To minimise animal suffering it is essential that the European Chemicals Agency (ECHA) and the European Commission adopt a standard policy that does not require the breeding of a second generation of animals or testing for developmental immunotoxicity or neurotoxicity endpoints.