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ShareThe OECD has published two new guidance documents (and two annexes) in order to standardise and ensure consistency in the use of integrated approaches to testing and assessment (IATA) in regulatory decision-making (here).
An IATA is an approach based on multiple information sources (e.g., physicochemical properties, in silico models, grouping and read-across approaches, in vitro methods, in vivo and human data). An IATA integrates and weighs relevant existing evidence and guides the targeted generation of new data, where required, in order to draw conclusions on the hazard and/or risk of the test substance.
The first guidance document (OECD GD No. 255) explains defined approaches to testing and assessment and provides templates for reporting defined testing approaches and individual information sources. The second guidance document (OECD GD No. 256) illustrates how the defined approaches and information sources should be documented in order to facilitate a harmonised methodology in their reporting. The annexes present specific skin sensitisation case studies and show how individual methods can be used with an IATA.