The US Environmental Protection Agency (EPA) released new guidance clarifying the number of treatment concentrations to be used in fish bioconcentration factor (BCF) studies for pesticide registration. The policy change brings the EPA into alignment with international regulations and will prevent as many as 240 fish from being used in BCF studies each year. Click here to access the guidance and learn more about the EPA’s other efforts to meet its goal of ending its reliance on and funding of toxicity tests on mammals by 2035. For more information about in vitro methods for BCF assessment, click here.