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ShareThis year, we celebrated the 10-year anniversary of PETA Science Consortium International and continued to build on the past decade’s achievements promoting non-animal toxicity test methods. In 2022 alone, we published groundbreaking papers on topics such as inhalation testing and establishing confidence in new toxicity test methods, awarded researchers critical tools to transition to animal-free testing, and expanded the reach of our collaborative projects to new partners in government, industry, academia, and elsewhere.
Take a look at some of the highlights of the year.
Publications
We published eleven papers:
- Lee KM, Corley R, Jarabek AM, Kleinstreuer N, Paini A, Stucki AO, Bell S. Advancing new approach methodologies (NAMs) for tobacco harm reduction: synopsis from the 2021 CORESTA SSPT—NAMs Symposium. Toxics. 2022;10(12):760.
- Hilton GM, Corvi R, Luijten M, Mehta J, Wolfe DC. Towards achieving a modern science-based paradigm for agrochemical carcinogenicity assessment. Regul Toxicol Pharmacol. 2023;137:105301.
- Groff K, Allen D, Fiebig M, Cosson P, Casey W, Clippinger AJ. An approach to identifying quality research antibodies. BioTechniques. 2022;73(4):167-170.
- Hilton GM, Adcock C, Akerman G, Baldassari J, Battalora M, Casey W, Clippinger AJ, Cope R, Goetz A, Hayes AW, Papineni S, Peffer RC, Ramsingh D, Riffle BW, Sanches da Rocha M, Ryan N, Scollon E, Visconti N, Wolf DC, Yan Z, Lowit A. Rethinking chronic toxicity and carcinogenicity assessment for agrochemicals project (ReCAAP): a reporting framework to support a weight of evidence safety assessment without long-term rodent bioassays. Regul Toxicol Pharmacol. 2022;131:105160.
- Felter SP, Bhat VS, Botham PA, Bussard DA, Casey W, Hayes AW, Hilton GM, Magurany KA, Sauer UG, Ohanian EV. Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop. Crit Rev Toxicol. 2022;51(8):653-694.
- Chary A, Groff K, Stucki AO, Contal S, Stoffels C, Cambier S, Sharma M, Gutleb AC, Clippinger AJ. Maximizing the relevance and reproducibility of A549 cell culture using FBS-free media. Toxicol In Vitro. 2022;83:105423.
- Miller-Holt J, Behrsing HP, Clippinger AJ, Hirn C, Stedeford TJ, Stucki AO. Use of new approach methodologies (NAMs) to meet regulatory requirements for the assessment of tobacco and other nicotine-containing products. Front Toxciol. Published online 9 September 2022.
- Stucki AO, Barton-Maclaren TS, Bhuller Y, Henriquez JE, Henry TR, Hirn C, Miller-Holt J, Nagy EG, Perron MM, Ratzlaff DE, Stedeford TJ, Clippinger AJ. Use of new approach methodologies (NAMs) to meet regulatory requirements for the assessment of industrial chemicals and pesticides for effects on human health. Front Toxciol. Published online 1 September 2022.
- Van der Zalm A, Barroso J, Browne P, Casey W, Gordon J, Henry TR, Kleinstreuer NC, Lowit AB, Perron M, Clippinger AJ. A framework for establishing scientific confidence in new approach methodologies. Arch Toxicol. 2022;96(11):2865-2879.
- Wolf DC, Bhuller Y, Cope R, Corvaro M, Currie R, Doe J, Doi A, Hilton G, Mehta J, Saltmiras D, Sewell F, Trainer M, Déglin SE. Transforming the evaluation of agrochemicals. Pest Manag Sci. Published online 30 August 2022.
- Rogers B, Brown J, Allen DG, Casey W, Clippinger AJ. Replacement of in vivo leptospirosis vaccine potency testing in the United States. Biologicals. 2022;78:36-44.
We co-edited the Research Topic “Chemical Testing Using New Approach Methodologies” in the journal Frontiers in In Vitro Toxicology. The research topic included 10 articles from more than 70 co-authors and highlighted diverse approaches to assessing chemical toxicity without the use of animals.
In addition, we’re collaborating on numerous other manuscripts that we’re looking forward to sharing with you in 2023.
Webinars
We co-organised three webinars:
- Webinar Series on the Use of New Approach Methodologies (NAMs) in Risk Assessment, cohosted with the US Environmental Protection Agency (EPA) and the Physicians Committee for Responsible Medicine
- Data-Driven Solutions to Reducing Animal Use in Ecotoxicity, with Michael Lowit, PhD, and Carlie LaLone, PhD, EPA
- Frameworks for Establishing Scientific Confidence in New Approach Methodologies: Part I, with Nicole Kleinstreuer, PhD, NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, and Tala Henry, PhD, EPA
- Flea and Tick Product Testing (invitation only)
- Implementing In Vitro/Ex Vivo Testing Strategies and Field Studies to Predict the Efficacy of Ectoparasiticides
We also moderated a joint webinar session for the Society of Toxicology’s (SOT) Carcinogenesis and Computational Toxicology Specialty Sections titled, “Integrating Computational Tools Into Carcinogenicity Assessments – Part II”.
Presentations
We gave more than 40 poster and oral presentations on topics such as reducing the number of fish used in aquatic toxicity testing, modernising carcinogenicity testing for agrochemical products, and using in vitro methods to assess respiratory toxicity. Click here for a selection of the presentations.
Awards
We launched the ongoing Recombinant Antibody Challenge, in which researchers from any sector can apply to win grants for free catalogue recombinant antibodies to replace animal-derived antibodies in research and testing.
We donated a laser-light beam opacitometer to the Institute for In Vitro Sciences, Inc. The equipment, worth US$20,000, can be used to replace the use of live rabbits in eye irritation tests.
We handed out ten early-career scientist awards. Our winners attended scientific conferences and workshops including the 61st Annual Society of Toxicology Meeting, the Summer School on Innovative Approaches in Science, the Lung In Vitro Event for Innovative & Predictive Models, and the Novel In Vitro Methods and AOP Approaches in Genetic Toxicology workshop. Four winners will attend the hands-on In Vitro Toxicology Training Course at the Institute for In Vitro Sciences in early 2023.
We received awards, too! We’re proud to announce that Science Consortium President Dr Amy Clippinger was named the winner of the 2022 SOT Enhancement of Animal Welfare Award in recognition of her achievements in advancing non-animal approaches to toxicology testing. Additionally, our co-authored papers on human-relevant approaches to assessing carcinogenicity and eye irritation received Best Paper awards from SOT specialty sections, and our poster providing a framework for building confidence in new approach methods received the American Society for Cellular and Computational Toxicology’s Edward Carney Predictive Toxicology Award.
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We’re seeking scientists who are passionate about modernising toxicity testing. Click here to view employment opportunities with Science Consortium members.
The Science Consortium Team
See our highlights from past years: