A Look Back at 2018

Here’s a quick look at some of our work in 2018:

• We organised two workshops:
  • With NICEATM, we co-organised a workshop on replacing the use of rabbits in pyrogen testing for medical device extracts (a workshop report will be submitted early next year).
  • We were on the planning committee for a NICEATM and International Alliance for Biological Standardization workshop on implementing non-animal approaches to vaccine testing.
• We organised three multi-part webinar series:
  • REACH webinar series
  • Inhalation webinar series
  • EPA webinar series
• We published five papers and have submitted one other:
  • Clippinger AJ, Allen D, Behrsing H, BéruBé KA, Bolger MB, Casey W, DeLorme M, Gaça M, Gehen SC, Glover K, Hayden P, Hinderliter P, Hotchkiss JA, Iskandar A, Keyser B, Luettich K, Ma-Hock L, Maione A, Makena P, Melbourne J, Milchak L, Ng S, Paini A, Page K, Patlewicz G, Prieto P, Raabe H, Reinke E, Roper C, Rose J, Sharma M, Spoo W, Thorne PA, Wilson DM, Jarabek AM. Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity. Toxicol In Vitro. 2018;52:131-145.
  • Clippinger AJ, Allen D, Behrsing H, Hinderliter PM, Landsiedel R, Reinke EN, Stone V. Nonanimal approaches to assessing the toxicity of inhaled substances: Current progress and future promise. Appl In Vitro Toxicol. 2018;4(2):82-88.
  • Clippinger AJ. Application of in silico and in vitro approaches to assess the toxicity of inhaled substances. Appl In Vitro Toxicol. 2018;4(2):81.
  • Strickland J, Clippinger AJ, Brown J, Allen D, Jacobs A, Matheson J, Lowit A, Reinke EN, Johnson MS, Quinn MJ Jr., Mattie D , Fitzpatrick SC, Ahir S, Kleinstreuer N, Casey W. Status of acute systemic toxicity testing requirements and data uses by U.S. regulatory agencies. Regul Toxicol Pharmacol. 2018;94:183-196.
  • Clippinger AJ, Allen D, Jarabek AM, Corvaro M, Gaça M, Gehen S, Hotchkiss JA, Patlewicz G, Melbourne J, Hinderliter P, Yoon M, Huh D, Lowit A, Buckley B, Bartels M, BéruBé K, Wilson DM, Indans I, Vinken M. Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report. Toxicol In Vitro. 2018;48:53-70.
  • Hilton G, Odenkirchen E, Panger M, Waleko G, Lowit A, Clippinger AJ. A retrospective review: Evaluation of the avian acute oral and sub-acute dietary toxicity test for pesticide registration. Submitted.
• As members of the International Council on Animal Protection in OECD Programmes (ICAPO), we collaborated with the European Commission and United States to update OECD guidance document 23 on aqueous-phase aquatic toxicity testing of difficult-to-test chemicals.
• We guest-edited one journal special issue on inhalation toxicity testing.
• We attended and chaired several sessions at scientific conferences and presented more than two dozen posters and oral presentations.
• We held in-person meetings with multiple regulatory agencies and companies.
• We organised two free in-person training sessions on in vitro methods for regulatory agencies in the US and Taiwan.
• We’re developing three adverse outcome pathways related to respiratory toxicity, including one for pulmonary fibrosis.

Looking towards next year, we are excited to continue and complete various current projects and to start new ones. Big items for next year include tackling carcinogenicity testing, eye irritation testing of agrochemical formulations, antitoxin production, feeding studies for genetically modified organisms, and inhalation testing.

We have 15 scientists on our global team and are expanding! Check out our job openings here.

OECD Working Party on Manufactured Nanomaterials

American Society for Cellular and Computational Toxicology

Meeting with the Union Minister of Science, Technology, and Earth Sciences and the Union Minister of Environment Forest